Status:
TERMINATED
Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Danish Center for Interventional Research in Radiation Oncology (CIRRO)
Conditions:
Colorectal Carcinoma
Liver Metastases
Eligibility:
All Genders
18-90 years
Phase:
PHASE3
Brief Summary
This randomized clinical phase III trial is testing the efficacy of radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) in the treatment of colorectal carcinoma liver metastases. ...
Detailed Description
Patients with 1-4 inoperable colorectal liver metastases, no more 4 cm in diameter are randomized to either RFA or SBRT. Primary end point i local progression free survival. Chemotherapy is allowed be...
Eligibility Criteria
Inclusion
- Adenocarcinoma of the colon or rectum
- Liver metastases
- Inoperable (technical or medical)
- 1-4 metastases
- Maximum 40 mm in diameter
- Suitable for both therapies, RFA and SBRT
Exclusion
- Uncontrolled extrahepatic disease and uncontrolled primary cancer
- Liver cirrhosis
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2014
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT01233544
Start Date
September 1 2010
End Date
December 1 2014
Last Update
May 12 2016
Active Locations (2)
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1
Aarhus University Hospital
Aarhus C, Denmark, 8000
2
Karolinska Institute, Huddinge
Stockholm, Sweden, 141 86