Status:
COMPLETED
Atypical Antipsychotic Treatment Effect On Brain Function In Schizophrenia Measured By FMRI
Lead Sponsor:
University of North Carolina, Chapel Hill
Conditions:
Schizophrenia
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The general aim is to compare the effects of typical and atypical antipsychotic medication on brain structure and function. A parallel group treatment trial will be utilized to compare the effects of ...
Detailed Description
The general aim of this study was to determine the neuroanatomic basis for cognitive pathology in schizophrenia, as well as the effects of treatment with typical and atypical antipsychotics on clinica...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Schizophrenia/Schizoaffective Subjects
- Men and women between ages of 18 to 60 inclusive, of any ethnic origin.
- Subjects must be right handed.
- DSM IV criteria for chronic schizophrenia or schizoaffective disorder.
- Good physical health as determined by complete physical examination, laboratory tests, and EKG
- Inclusion Criteria for Healthy Control Subjects:
- 1\. Fifteen individuals, matched to the patient subjects on the basis of age, gender, parental SES, handedness.
Exclusion
- Exclusion Criteria for Schizophrenia/Schizoaffective Subjects
- Previous poor response or adverse side effects to thiothixene, olanzapine or risperidone.
- Left handedness
- Epilepsy, HIV, or current myeloproliferative disorder
- Current severe major depression.
- Current or past history of Substance Dependence (except caffeine or nicotine)
- Criteria for active Substance Abuse within past 30 days
- Learning disability
- Mental Retardation
- Foreign metal objects or implants as determined by MRI safety questionnaires
- If judged unsuitable for the study based on other medical or psychiatric condition according to the PIs best clinical judgment.
- No depot neuroleptic within 60 days before the day of randomization.
- Women who are pregnant or breastfeeding, and/or unwilling to take a pregnancy test.
- Exclusion Criteria for Healthy Control Subjects
- 1\. History of psychiatric disorder or current medical illness
Key Trial Info
Start Date :
January 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT01234454
Start Date
January 1 2002
End Date
December 1 2007
Last Update
April 3 2015
Active Locations (1)
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1
Unc Psychiatry
Chapel Hill, North Carolina, United States, 27599