Status:
COMPLETED
Relationship of Urine Sodium Excretion to Central Blood Pressure and Aortic Pulse Wave Velocity
Lead Sponsor:
DongGuk University
Collaborating Sponsors:
The Korean Society of Cardiology
Conditions:
Hypertension
Eligibility:
All Genders
35-65 years
Brief Summary
One interesting area is the relationship of high salt intake and central aortic blood pressure. High salt intake is associated development of hypertension and cardiovascular mortality. Central aortic ...
Detailed Description
Measurements: should be performed for 2 days 1. 24 hour urine Na, K and Creatinine, 24 hour urine amount 1. Calculation of urine completeness index : Cr/(21 x Bwt) 2. Definition of complete ur...
Eligibility Criteria
Inclusion
- subjects without hypertension: n=100
- subjects with hypertension, not treated at least within 6months: n=100
Exclusion
- secondary hypertension
- known diabetes (HbA1C \>7.5%)
- night worker
- stage 3 hypertension
- renal artery stenosis
- primary aldosteronism
- elevated GOT and/or glutamate-pyruvate transaminase \> 2 fold of normal range
- heart failure, significant arrhythmia, angina, myocardial infarction, stroke, carotid stenosis
- pregnancy
- autoimmune disease, debilitating disease
- significant liver disease; active hepatitis, liver cirrhosis
- alcoholics
- Renal disease: Cr \> 1.2 and/or proteinuria
- Medication affecting blood pressure and/or vascular stiffness, including lipid lowering agents
Key Trial Info
Start Date :
May 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01237717
Start Date
May 1 2010
End Date
December 1 2011
Last Update
January 23 2013
Active Locations (1)
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1
Dongguk University Ilsan Hospital
Goyang, Gyenggi, South Korea, 410-773