Status:
UNKNOWN
Injectable Collagenase For Burns' Associated Contracture
Lead Sponsor:
Sheba Medical Center
Conditions:
Burn's Associated Contracture
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
Brief Summary
A pilot experiment to test the efficiency of the enzyme Collagenase in treating contractures which result's from burn's healing process. So far, treatment of choice in patients with burn's created mo...
Detailed Description
Scientific Background: Contracture is defined as a scar tissue that replaces the original tissue and leads to shortening and tightening of the muscle results in a range of motion limitation and defor...
Eligibility Criteria
Inclusion
- age - 18+
- Contracture is 6 month old or more
- Place of contracture in a flex-ext joint only (e.g knee, elbow)
- Contracture leads to 15% decrease in joint range of movement vs anatomical range
- Physiotherapy can no longer improve those patients condition
Exclusion
- Any systemic condition involving skin or soft tissue disease
- skin disease related to elastin, collagen or keratinocytes
- Known allergy to Clostridium Collagenase enzyme
- Psychiatric, Prisoners, Soldiers, Pregnant women
- Patients whom due to their home location will not be available to frequent surveillance
Key Trial Info
Start Date :
March 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2011
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01237964
Start Date
March 1 2011
End Date
August 1 2011
Last Update
November 10 2010
Active Locations (1)
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1
Sheba Hospital
Ramat Gan, Israel