Status:
TERMINATED
Emotional Memory Reactivation in Posttraumatic Stress Disorder
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Posttraumatic Stress Disorder
Eligibility:
All Genders
18-50 years
Phase:
PHASE3
Brief Summary
Converging lines of evidence have implicated the amygdala in the pathophysiology of posttraumatic stress disorder. The primary purpose of our study is to assess the effect of propanolol, a beta adren...
Detailed Description
Post-traumatic stress disorder (PTSD) is a type of anxiety disorder that's triggered by an extremely traumatic event. Traumatic events that may trigger PTSD include violent personal assaults, accident...
Eligibility Criteria
Inclusion
- Patients of French mother language
- Right-handed patients
- Signature of the consent
- Patients:
- Patients whose diagnosis of PTSD according to the criteria of the DSM IV-TR is established
- PTSD whose evolution is not chronic
- Established PTSD : Symptoms presents for at least 1 month
- PTSD consecutive to a unique traumatic event
- Controls :
- The healthy controls will have sudden a traumatism of the same nature or the nature comparable to that of the patients suffering from PTSD, but they will not have developed pathology
- Subjects having undergone a traumatism dating less than 3 months
- Examples of traumatic events: aggression, accident of the public highway, the occupational accident
Exclusion
- The PTSD consecutive to several traumatic events
- Patients treated by a substance crossing the blood-brain barrier (with the exception of the antidepressants of the family of the ISRS which can be indicated in the treatment of PTSD)
- Histories of epilepsy or significant loss of consciousness of any origin, including post-traumatic
- Any psychiatric or somatic significant pathology
- The psychiatric histories in particular of suicide attempt
- The pregnant or breast-feeding women
- Contraindications in the propanolol
- Consumption of psychoactive drugs detected in urines
- Excessive alcohol consumption
- The persons not being capable of understanding or of reading the information describing the study
- The patients refusing to sign the form of consent of participation for the study
- The left-handed or ambidextrous patients
- The patients without the general regime of the health insurance
- The patients under guardianship or incapable major
- The patients who will not be capable of supplying a documentary evidence of identity the day of the inclusion
- Contraindication in the practice of a MRI
- The patients or the controls refusing the medical and psychiatric balance assessment of screening cannot participate in the study
- Strong probability of not compliance to the protocol or of abandonment in the course of study
- Taking of a speechless medicine, in particular beta-blocking
- Participating in phase of exclusion from a previous study
Key Trial Info
Start Date :
September 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01239173
Start Date
September 1 2010
End Date
February 1 2012
Last Update
July 26 2012
Active Locations (1)
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1
Saint-Antoine Hospital, Psychiatriy unit
Paris, Île-de-France Region, France, 75012