Status:
COMPLETED
Iron Mediated Vascular Disease in Sickle Cell Anemia Patients
Lead Sponsor:
Children's Hospital Los Angeles
Conditions:
Sickle Cell Disease
Eligibility:
All Genders
13+ years
Brief Summary
The purpose of this research study is to determine the frequency and severity of iron overload in patients with Sickle Cell Anemia and its relationship to blood vessel function. The investigators hypo...
Detailed Description
Patients with sickle cell anemia often require blood transfusion as part of the treatment for their disease. Each teaspoon of transfused blood contains about 5 mg of iron and the levels of iron in sic...
Eligibility Criteria
Inclusion
- Age \> 13 years
- Documented diagnosis of sickle cell anemia (SS, SC, Sß0, Sß+)
- Transfused no more than 8 times in a year.
Exclusion
- Cardiac pacemaker, implantable neurostimulator or other MRI incompatible device.
- History of extreme claustrophobia in MRI machine or other reason for inability to do MRI without sedation.
- Inability to be positioned on the MRI table for sufficient time to complete the MRI exams.
- Any medical or psychological condition that, in the opinion of the local investigator, would make it unsafe or ill-advised for the subject to participate.
- Currently not receiving chronic transfusion therapy, defined as greater than 8 transfusions per year.
Key Trial Info
Start Date :
December 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT01239901
Start Date
December 1 2009
End Date
October 1 2018
Last Update
January 10 2019
Active Locations (1)
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1
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027