Status:
COMPLETED
Plasmodium Falciparum Clearance Rates in Response to Artesunate in Eastern Cambodia
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsors:
National Centre for Parasitology, Entomology and Malaria Control, Cambodia
Conditions:
Malaria
Eligibility:
All Genders
1+ years
Brief Summary
Plasmodium falciparum parasite clearance rates (PCRs) after oral artesunate treatment of patients with uncomplicated malaria were recently found to be significantly slower in Pailin (Western Cambodia)...
Detailed Description
Plasmodium falciparum parasite clearance rates (PCRs) after oral artesunate treatment of patients with uncomplicated malaria were recently found to be significantly slower in Pailin (Western Cambodia)...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age 2 to 65 years, inclusive
- Uncomplicated P. falciparum malaria.
- Tympanic temperature greater than or equal to 37.5 degree C or history of fever within the last 24 h.
- P. calciparum asexual parasite density 10,000 200,000/microL, Inclusive.
- Willingness to allow the storage of blood samples collected as part of the study.
- Willingness and ability of the patient/guardians to comply with the protocol for the duration of the study.
- EXCLUSION CRITERIA:
- Severe malaria: diminished consciousness, respiratory distress, severe prostration, anuria, jaundice, hemoglobinuria, repetitive vomiting, or cessation of eating and drinking.
- Non-malaria etiology of febrile illness (e.g., respiratory tract infection) evident on clinical examination.
- Hematocrit \< 25 percent
- Treatment of present symptoms with an artemisinin compound or artemisinin-based combination therapy within the previous 7 days.
- Pregnancy or breastfeeding
- History or allergy or known contraindication to artemisinins or piperaquine
- Splenectomy.
Exclusion
Key Trial Info
Start Date :
October 24 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 11 2013
Estimated Enrollment :
415 Patients enrolled
Trial Details
Trial ID
NCT01240603
Start Date
October 24 2010
End Date
September 11 2013
Last Update
April 5 2018
Active Locations (1)
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1
National Center for Parasitology, Entomology, and Malaria Controk, Ministry of H
Phnom Penh, Cambodia