Status:
COMPLETED
Blood Oxygen Level Dependent Magnetic Resonance Imaging (BOLD MRI) and Fluorothymidine Positron Emission Tomography (FLT PET) in Patients With Locally Advanced Breast Cancer Undergoing Neoadjuvant Chemotherapy
Lead Sponsor:
Ontario Clinical Oncology Group (OCOG)
Conditions:
Locally Advanced Breast Cancer (LABC)
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
The objective of this pilot study is to determine the effectiveness of Fluorothymidine Positron Emission Tomography (FLT PET) and Blood Oxygen Level Dependent Magnetic Resonance Imaging (BOLD MRI) in ...
Eligibility Criteria
Inclusion
- Histologic proof of breast cancer (invasive ductal or lobular carcinoma). Breast sarcoma and lymphoma are not eligible.
- Clinical diagnosis of locally advanced breast cancer (Stage IIB (T3,N0,M0), Stage IIIA, IIIB, or IIIC, according to American Joint Committee on Cancer (AJCC) Tumour-Node-Metastasis (TNM) Cancer Staging), including inflammatory breast cancer.
- Ability to undergo neoadjuvant chemotherapy.
Exclusion
- Evidence of metastatic disease (identified on chest x-ray, liver ultrasound, bone scan or other imaging tests);
- Previous chemotherapy or hormonal therapy for breast cancer;
- Significant concurrent medical problems that result in the patient being unfit for surgery (e.g. uncontrolled diabetes, active cardiac disease, severe chronic obstructive pulmonary disease);
- Known pregnancy or lactating female (e.g. positive serum beta human chorionic gonadotropin (B-hCG) pregnancy test);
- Inability to lie supine for imaging with Positron Emission Tomography (PET);
- Any contraindication to undergoing Magnetic Resonance Imaging (MRI) or PET;
- Currently receiving Antabuse;
- Inability to provide informed consent (e.g. dementia or severe cognitive impairment).
Key Trial Info
Start Date :
April 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT01240681
Start Date
April 1 2011
End Date
January 1 2015
Last Update
March 11 2015
Active Locations (4)
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1
Juravinski Cancer Centre
Hamilton, Ontario, Canada, L8V5C2
2
London Health Sciences Centres - London Regional Cancer Program
London, Ontario, Canada
3
Thunder Bay Regional Health Sciences Centre
Thunder Bay, Ontario, Canada, P7B6V4
4
Sunnybrook Odette Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5