Status:
COMPLETED
Effect of Fish Oil on Insulin Sensitivity
Lead Sponsor:
University of Aberdeen
Conditions:
Metabolic Syndrome X
Type 2 Diabetes Mellitus
Eligibility:
All Genders
40-69 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether a prolonged (9 month) high (6g/d) of marine oil improves insulin sensitivity and glucose control in subjects with impaired glucose regulation.
Detailed Description
The incidence of Type 2 diabetes is related both to age and obesity. The disease impacts on quality of life and treatments represent a major health cost. Prevention or delayed onset of the disease rem...
Eligibility Criteria
Inclusion
- Men and post-menopausal women aged 40-65 years
- Recruited from the surrounding community of Aberdeen
- Insulin resistance with either
- venous plasma fasting glucose \> 5.0, \< 7.0 mmo/l,
- venous plasma 2-h 75-g OGTT \> 5.0, \< 11.1 mmol/l
- newly diagnosed with type 2 diabetes; must be asymptomatic and detected during our screenings and not require oral hypoglycemic or insulin therapy, HbA1c \< 7.0%
Exclusion
- Diabetes requiring oral hypoglycemic therapy or insulin
- Treatment with anticoagulants, regular steroids or non-steroidal anti-inflammatory drug treatment, tricyclic antidepressants, anti-arrhythmics
- Hepatic failure
- Renal failure
- Significant respiratory disease
- Anaemia
- Cardiovascular disease
- Malignancy
- Thromboembolic or coagulation disorders
- Alcoholism or other substance misuse
- Eating disorders or significant psychiatric disorders
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT01241474
Start Date
February 1 2009
End Date
June 1 2012
Last Update
August 7 2012
Active Locations (1)
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1
Rowett Institute of Nutrition and Health, University of Aberdeen
Aberdeen, United Kingdom, AB21 9SB