Status:
COMPLETED
Taurolidine in Haemodialysis Catheter Related Bacteraemia
Lead Sponsor:
Imperial College Healthcare NHS Trust
Conditions:
Renal Dialysis
Catheter-Related Infections
Eligibility:
All Genders
18-120 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether taurolidine with heparin locking solution prevents recurrence of central venous catheter related blood stream infections in haemodialysis patients.
Detailed Description
Infections related to long-term haemodialysis catheters are associated with significant morbidity. A high proportion of those people initially treated with antibiotics to clear a catheter infection de...
Eligibility Criteria
Inclusion
- Haemodialysis patients established on dialysis for greater than 90 days who dialyse in-centre at any of the satellite dialysis units of Imperial College Healthcare NHS Trust
- All patients with a recent catheter related bacteraemia with an identified organism grown on microbiological culture and treated without catheter removal will be eligible for inclusion.
Exclusion
- Those individuals in whom attempted catheter salvage is clinically not indicated.
- Unable to provide informed consent
- Known allergy to sodium citrate, heparin or taurolidine.
- Bleeding diathesis or physical cause for active bleeding.
Key Trial Info
Start Date :
August 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT01243710
Start Date
August 1 2010
End Date
December 1 2012
Last Update
July 30 2020
Active Locations (1)
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1
Imperial College Healthcare NHS Trust
London, United Kingdom, W12 0HS