Status:
UNKNOWN
Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study
Lead Sponsor:
Yoshio Matsui
Conditions:
Hypertension
Eligibility:
All Genders
20-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare of carvedilol, a vasodilating beta-blocker and bisoprolol, a beta1- selective beta-blocker for reducing the central pulse pressure and thereby left ventricular ...
Detailed Description
Carvedilol and bisoprolol are established beta-blockers for treating hypertension or chronic heart failure because these beta-blockers have cardio-protective effects. Recent studies have shown that th...
Eligibility Criteria
Inclusion
- Never-treated hypertensive subjects, aged 20-80 years (at the time of informed consent), regardless of sex
- Clinic systolic BP/diastolic BP \> 140/90 mmHg in a sitting position.
Exclusion
- Beta-blocker contraindications(asthma, COPD…)
- Heart rate less than 55 bpm
- Subjects treated with nitrates
- Grade 3 hypertension (≥180 and/or ≥110 mmHg)
- Secondary hypertension or malignant hypertension
- History of heart failure, coronary artery disease, and stroke
- Arrhythmia
- Renal dysfunction (serum creatinine ≥2.0 mg/dl)
- Hepatic dysfunction (AST and/or ALT ≥100 IU/l)
- A history of or a suspected malignant tumor within 5 years of enrollment
- Chronic inflammatory disease
- Pregnancy, childbearing potential with inadequate contraception, breast feeding
- Inability to give informed consent
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2013
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01243827
Start Date
November 1 2010
End Date
April 1 2013
Last Update
July 19 2012
Active Locations (1)
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1
Iwakuni City Medical Center
Yamaguchi, Japan