Status:
COMPLETED
The Effect of Food Stimuli on the Calorie Restriction Response in Healthy Subjects
Lead Sponsor:
Leiden University Medical Center
Collaborating Sponsors:
Center for Medical Systems Biology
Roba Metals BV, IJsselstein
Conditions:
Calorie Restriction
Aging
Eligibility:
MALE
18-70 years
Phase:
NA
Brief Summary
Calorie restriction extends life span and prevents aging-related diseases in several species. Odorants from live yeast restrain the beneficial effects of calorie restriction in Drosophila Melanogaster...
Eligibility Criteria
Inclusion
- Caucasian male volunteers
- Age \> 18 years and \< 70 years
- Body mass index (BMI) \> 20 kg/m2 and \< 25 kg/m2
- Fasting serum glucose (FSG) \< 6.1 mmol/L
Exclusion
- Any significant chronic of hereditary disease (including renal, hepatic or endocrine disease)
- Any significant abnormal laboratory results found during the medical screening procedure
- Any use of medication (except for NSAID)
- Anosmia or any other (acquired) loss of olfaction (ea. rhinitis)
- Recent weight changes or attempts to loose weight (\> 3 kg weight gain or loss, within the last 3 months)
- Difficulties to insert an intravenous catheter
- Smoking
- MRI contraindications
- Recent blood donation (within the last 3 months)
- Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2009
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01243879
Start Date
July 1 2008
End Date
March 1 2009
Last Update
February 21 2020
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