Status:
TERMINATED
Ephedrine vs Phenylephrine - ECG Changes
Lead Sponsor:
University College London Hospitals
Collaborating Sponsors:
Obstetric Anaesthetists' Association United Kingdom
Conditions:
Spinal Anesthesia
Pregnancy
Eligibility:
FEMALE
18+ years
Phase:
PHASE4
Brief Summary
ECG changes during caesarean section are common. Incidence of ST depression on the ECG is up to 81% in some studies. Although this may indicate inadequate oxygen supply to the heart muscle (myocardial...
Eligibility Criteria
Inclusion
- Able to give written informed consent
- \>37/40 weeks gestation
- Singleton pregnancy
- Elective caesarean section under spinal anaesthesia
- In good general health (American Society of Anesthesiology Category 1 or 2, fit and well or with mild systemic disease that has no impact on physical activity )
Exclusion
- Circulatory disease (eg pre-existing hypertension)
- Cardiac disease/medications (e.g. angina, cardiomyopathy, B Blocker medication)
- Pregnancy related disease (eg pre-eclampsia)
- Diabetes pre-existing the pregnancy
- Hyperthyroidism
- Renal Disease
- Closed-angle glaucoma
- Patients on monoamine oxidase inhibitors
- In active labour
- Emergency caesarean section
- Fetal abnormalities
- Contraindications to spinal anaesthesia
- Height \>6 feet/180cm / Height \<5 feet/150cm
- Body mass index (BMI) \<19 or \>35
Key Trial Info
Start Date :
April 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2016
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT01243970
Start Date
April 1 2012
End Date
January 1 2016
Last Update
October 26 2016
Active Locations (1)
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1
University College London Hospital
London, United Kingdom, NW1 2BU