Status:
COMPLETED
Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover
Lead Sponsor:
University of Florida
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
60-85 years
Phase:
NA
Brief Summary
The purpose of this study is to determine if a 4 month resistance exercise program can reduce knee osteoarthritis pain functional impairment and cartilage turnover.
Eligibility Criteria
Inclusion
- Osteoarthritis (OA) of the knee for \>6 months
- moderate to severe pain immediately following a 50-foot walk
- knee pain primarily due to tibiofemoral OA and not from patellofemoral OA
- bilateral standing anterior-posterior radiograph demonstrating grade 2 or 3 OA of the target knee
- willing and able to participate in regular exercise for four months
- free from musculoskeletal limitations that would preclude resistance exercise participation
- free of abnormal cardiovascular responses during the screening graded maximal walk test
Exclusion
- unable to walk
- regular resistance exercise training (\>3X week) within the past 6 months
- specific low back pain or acute back injury
- spinal stenosis that precludes walking one block due to neurogenic claudication
- any major injury to either knee within the prior 12 months
- any surgery to either knee within the last 12 months
- lumbar radiculopathy
- vascular claudication
- significant anterior knee pain due to diagnosed isolated patella-femoral syndrome or chondromalacia in either knee
- have had corticosteroid or viscosupplement injections within three months of study participation
- have added new over the counter or prescription pain medication within two months of study participation
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT01245283
Start Date
November 1 2010
End Date
June 1 2013
Last Update
December 5 2014
Active Locations (1)
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1
UF&Shands Orthopaedics and Sports Medicine Institute
Gainesville, Florida, United States, 32607