Status:
TERMINATED
Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome
Lead Sponsor:
Region Skane
Conditions:
Adrenal Tumour With Mild Hypercortisolism
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Incidental findings of adrenal tumours,"incidentalomas", occur in 1-5 % in the general population and 10-25 % of these patients will exhibit biochemical mild hypercortisolism. Although the patients do...
Detailed Description
Adrenal incidentalomas, adrenal tumours detected without symptoms and signs of hormonal hypersecretion or malignancy, are common. Depending on modality (MRI, CT. Ultrasonography) adrenal tumours occur...
Eligibility Criteria
Inclusion
- Adrenal tumour with biochemical mild hypercortisolism defined as pathological dexamethasone suppression test (cortisol \> 50 nmol/L at 8.00 am after 1 mg dexamethasone at 10 pm, plus one of the following criteria
- Low or suppressed adrenocorticotropic hormone (ACTH)
- Low or suppressed dehydroepiandrosterone (DHEA)
- No or pathological circadian rhythm of cortisol
Exclusion
- Increased levels of 24 hours urinary excretion of cortisol
- Pregnancy or lactation
- Inability to understand information or to comply with scheduled follow-up
- Mild hypercortisolism with bilateral adrenal tumours, without a gradient (lateralization on venous sampling)
Key Trial Info
Start Date :
June 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2024
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT01246739
Start Date
June 1 2011
End Date
February 1 2024
Last Update
April 10 2024
Active Locations (4)
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1
Århus University Hospital
Aarhus, Denmark, 8000
2
Haukeland University Hospital
Bergen, Norway, 5021
3
Sahlgrenska University Hospital
Gothenburg, Sweden, 41345
4
Skåne University Hospital-Lund, Department of Surgery
Lund, Sweden, 22185