Status:
COMPLETED
Metformin in Chronic Obstructive Pulmonary Disease
Lead Sponsor:
St George's, University of London
Collaborating Sponsors:
Medical Research Council
British Lung Foundation
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
35+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine the effect of a tablet medication, called metformin, in flare-ups (exacerbations) of chronic obstructive pulmonary disease. The investigators believe that met...
Detailed Description
Does metformin lower the blood sugar level in patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD)? COPD is the fourth leading cause of death worldwide, and a major c...
Eligibility Criteria
Inclusion
- Diagnosis of COPD
- Hospitalisation for exacerbation of COPD
- Age ≥35 years
- Expected to remain in hospital for at least 48 hours
Exclusion
- Prior diagnosis of diabetes mellitus requiring insulin or oral hypoglycaemic therapy
- Hypersensitivity to metformin hydrochloride or to any of the excipients
- Renal impairment
- Severe sepsis
- Metabolic acidosis
- Decompensated type 2 respiratory failure
- Severe congestive cardiac failure
- Acute coronary syndrome
- Hepatic insufficiency
- Excessive alcohol consumption
- Malnourished or at high risk for malnutrition
- Moribund or not for active treatment
- Admitted to critical care unit
- Unable to give informed consent
- Pregnancy or lactation
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT01247870
Start Date
January 1 2011
End Date
May 1 2014
Last Update
May 7 2015
Active Locations (9)
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1
North Tees and Hartlepool NHS Trust
Hartlepool, Cleveland, United Kingdom, TS24 9AH
2
University Hospitals of Morecambe Bay NHS Trust
Lancaster, Cumbria, United Kingdom, LA9 7RG
3
East Sussex Healthcare NHS Trust
Hastings, East Sussex, United Kingdom, TN37 7PT
4
Blackpool Teaching Hospitals NHS Trust
Blackpool, Lancashire, United Kingdom, FY3 8NR