Status:
COMPLETED
Impact of Buttermilk on Cholesterol Concentration and Homeostasis
Lead Sponsor:
Laval University
Collaborating Sponsors:
Dairy Farmers of Canada
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The role of low-density lipoprotein cholesterol (LDL-C) in the pathogenesis of cardiovascular disease (CVD) and the clinical benefit of lowering LDL-C in high-risk patients have both been well establi...
Detailed Description
The proposed research will be undertaken as a double-blind randomized cross-over study with participants being subjected to 2 consecutive treatments of 4 weeks each, in random order, during which they...
Eligibility Criteria
Inclusion
- Healthy men and women aged between 18 and 65 years
- For pre-menopausal women: regular menstrual cycle for the last 3 months (25- 35 days), using or not contraceptive agents
- LDL-Cholesterol concentration between 3.2 and 4.5 mmol/L
- A 10-yr calculated Framingham risk below 10%.
- Stable body weight (+/- 2 kg) for 6 months before the beginning of the study
- Smoking or not
Exclusion
- Previous history of cardiovascular disease, type 2 diabetes and monogenic dyslipidemia
- Subjects taking medications for hyperlipidemia or hypertension
- Endocrine disorders
- Body mass index \> 35 kg/m2
- Food allergies
- Men and women with extreme nutritional habits such as vegetarism or alcohol consumption \> 2 drinks/day
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT01248026
Start Date
January 1 2011
End Date
December 1 2011
Last Update
January 23 2013
Active Locations (1)
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1
Institute of Nutraceutical and Functional Foods (INAF), Laval University
Québec, Quebec, Canada, G1V 0A6