Status:
COMPLETED
Effect of the Intensity of Continuous Renal Replacement Therapy
Lead Sponsor:
Zhejiang University
Conditions:
Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
Eligibility Criteria
Inclusion
- met at least one of the following criteria: oliguria (urine output less than 100 mL in a 6 h period and unresponsive to fluid resuscitation), serum potassium concentration more than 6.5 mmol/L, severe acidemia (pH \< 7.2), serum creatinine more than 250 µmol/L, or presence of severe organ edema (e.g. pulmonary edema).
Exclusion
- were presence of a malignant tumor, chronic renal insufficiency (serum creatinine \>133 µmol/L), or receiving any kind of renal replacement therapy before randomization.
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT01251081
Start Date
January 1 2004
End Date
June 1 2010
Last Update
December 1 2010
Active Locations (1)
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1
Kidney disease center, the first affiliated hospital, medical college of Zhejiang university
Hangzhou, Zhejiang, China, 310003