Status:
COMPLETED
Lidocaine: Effect of Lidocaine in Chronic Cough
Lead Sponsor:
Manchester University NHS Foundation Trust
Conditions:
Chronic Cough
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
People cough in order to clear their airways. Most coughs are caused by viruses and settle down by themselves, but some people develop persistent coughing which can be anywhere from 8 weeks to several...
Eligibility Criteria
Inclusion
- Male and female subjects, age 18 years and over.
- History of cough for more than 8 weeks.
- Normal chest x ray
- Chronic idiopathic cough or chronic cough resistant to treatment of specific triggers.
Exclusion
- Smoking status:
- Current smokers
- Ex smokers with history of smoking \> 20 pack years or those who have given up \< 6 months ago.
- Prohibited medications:
- Use of medications likely to suppress / affect cough including codeine, morphine, pregabalin, gabapentin, amitriptylline, angiotensin converting enzyme inhibitors (type 1) and baclofen.
- Use of any anti-arrhythmic medication.
- Use of cimetidine, beta blockers, or diuretics.
- Cardiovascular conditions:
- Sinoatrial disease, bradycardia or all types of heart blocks.
- History of ischaemic heart disease or heart failure.
- Clinically significant abnormal electrocardiogram (ECG) at Screening or Baseline.
- History of cardiac surgery
- Respiratory conditions:
- o Asthma.
- Central nervous system / Peripheral nervous system conditions:
- Epilepsy.
- Myasthenia gravis.
- Miscellaneous:
- History of hepatic or renal dysfunction.
- Porphyria
- History of hypersensitivity to Lidocaine or related drugs.
- Pregnancy or breast feeding.
- Participation in another trial within the preceding 6 weeks.
- Trauma or ulceration to oral mucosa.
- History of chest or upper airway infection within the past 6 weeks.
- Conditions which may affect cough response such as stroke, diabetes, Parkinson's Disease.
Key Trial Info
Start Date :
February 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2011
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01252225
Start Date
February 1 2011
End Date
May 1 2011
Last Update
September 16 2011
Active Locations (1)
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1
University Hospital of South Manchester
Manchester, United Kingdom, M23 9LT