Status:
COMPLETED
Evaluation of the Role of Prostaglandins in Radiation-induced Mucositis
Lead Sponsor:
University of Vermont
Conditions:
Cancer of the Head and Neck
Radiotherapy
Eligibility:
All Genders
18+ years
Brief Summary
This study will evaluate the role of cyclooxygenase pathways in radiation-induced and chemoradiation-induced mucositis.
Detailed Description
Oral mucositis is a significant toxicity of radiation therapy and chemoradiation therapy in head and neck cancer patients. However the mechanisms that induce such mucositis are not completely understo...
Eligibility Criteria
Inclusion
- Histologically proven locoregional Stage 4 squamous cell carcinoma of the oral cavity, larynx, oropharynx or hypopharynx
- Receiving radiation therapy or chemoradiation therapy to the oropharynx
- Older than 18 years old
- ECOG performance status of 0-2
- Life expectancy greater than 2 months
- Signed informed consent
Exclusion
- Previous chemotherapy for this malignancy
- Previous radiotherapy to the head and neck
- Other cancer diagnosis within the last 5 years except for non-melanoma skin cancer or non-metastatic prostate cancer
- Patient taking NSAIDs
Key Trial Info
Start Date :
December 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT01252498
Start Date
December 1 2010
End Date
September 1 2012
Last Update
February 4 2014
Active Locations (1)
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1
Fletcher Allen Health Care
Burlington, Vermont, United States, 05401