Status:
COMPLETED
Respiratory Impedance and Obliterative Bronchiolitis
Lead Sponsor:
IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Conditions:
Hematopoietic Stem Cell Transplantation
Obliterative Bronchiolitis
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The aim of the present study will be to test the hypothesis that changes in within-breath total respiratory input impedance (Zrs) may provide an early evidence of obliterative bronchiolitis after allo...
Detailed Description
1.0 INTRODUCTION * Shortly after the introduction of allogeneic HSCT in clinical practice, it was recognized that standard pulmonary function tests (PFTs) are sensitive enough to detect HSCT-related ...
Eligibility Criteria
Inclusion
- consecutive, clinically-stable, outpatients undergoing allogeneic HSCT (sourcing from bone marrow) for hematological malignancies
- values of standard PFTs within normal range before HSCT
- good collaboration during the maneuvers
Exclusion
- patients showing any spirometric and/or volumetric abnormality before HSCT
- poor collaboration and/or coordination during the maneuvers
- any clinically-significant respiratory disease (bronchial asthma, COPD, cystic fibrosis, etc.) before HSCT
Key Trial Info
Start Date :
December 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT01255449
Start Date
December 1 2010
End Date
June 1 2012
Last Update
January 31 2013
Active Locations (1)
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1
U.O. Medicina Preventiva e del Lavoro, Laboratorio di Fisiopatologia Respiratoria, IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro
Genova, Italy, 16132