Status:
WITHDRAWN
Oral Steroid Treatment for Chronic Rhinosinusitis
Lead Sponsor:
Oregon Health and Science University
Conditions:
Chronic Rhinosinusitis
Eligibility:
All Genders
18+ years
Brief Summary
Despite the common use of oral steroids in the management of chronic rhinosinusitis (CRS), the natural history and efficacy of this treatment modality has not been fully elucidated. Specifically, pati...
Eligibility Criteria
Inclusion
- Adult ( \> 18 years of age)
- CRS defined by 2007 Adult Sinusitis Guidelines.12
- Subject must be able to complete QoL questionnaires written in English
- Previous sinus surgery including unilateral or bilateral total ethmoidectomy
- Minimum nasal blockage score on SinoNasal Outcomes Test-22 (SNOT-22) \> 3
- Severe sinonasal inflammation where the next treatment option is a 12- day oral prednisone taper
- Obstruction of the ethmoid sinus region or middle meatus eligible for revision endoscopic sinus surgery
- Lund-Kennedy endoscopy score \> 4
- Elects 12-day tapering dose of oral steroids (Prednisone) as a next treatment option
Exclusion
- Unable to complete questionnaires or clinical testing or cooperate with study evaluations in English
- Contra-indication to oral steroids
- Endoscopic sinus surgery \< 3 months of presentation
- Completed course of oral corticosteroids within the previous 3 month period
- Subjects presenting with unilateral chronic rhinosinusitis
- Pregnancy or possibility to become pregnant during the study
Key Trial Info
Start Date :
December 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2011
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01255683
Start Date
December 1 2010
End Date
November 1 2011
Last Update
April 22 2015
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239