Status:
COMPLETED
Optimization of Arterial Oxygen Transport by Positive End-expiratory Pressure Variation in Acute Respiratory Distress Syndrome
Lead Sponsor:
Rennes University Hospital
Conditions:
Respiratory Distress Syndrome, Adult
Eligibility:
All Genders
18+ years
Brief Summary
Despite improving in the treatment of acute respiratory distress syndrome (ARDS), this affection keep an elevate rate of death. The strategy of mechanical ventilation is more and more under definite p...
Eligibility Criteria
Inclusion
- patient presenting a Acute Respiratory Distress Syndrone (ARDS) definite by : acute respiratory failure, bilateral alveolo-interstitial infiltrate on chest radiography, absence of increased left ventricular filling pressure, partial pressure of oxygen in arterial blood (PaO2)/Fraction of inspired oxygen(FiO2) \<200 and Positive End-Expiratory Pressure (PEEP) \> or equal to 5 cmH2O
- Need to invasive mechanical ventilation
- Precedent criteria persisting at least 6 hours
- Haemoglobin \> 8g/dl
- Ramsay score at 6
Exclusion
- Participation to en other study on the Acute Respiratory Distress Syndrone (ARDS) with the same end-point
- Presence of external circulatory assist
- Left Ventricular Ejection fraction (LVEF)or Left ventricular shortening fraction (LVSF)\< 40% after correction of hypovolemia and/or vasoplegia
- Infusion of inotrope
- Presence of Acute Pulmonary Heart
- Following procedure : ExtraCorporeal Membrane Oxygenation(ECMO), prone position, inhalation of Nitrogen dioxyde
- Presence of a chest tube
- Pregnant or nursing mother
- Less than 18 years old
- Complete arrhythmia by atrial fibrillation
- Person under justice protection
Key Trial Info
Start Date :
January 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01256333
Start Date
January 1 2011
Last Update
July 3 2013
Active Locations (2)
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1
Perigueux Hospital
Périgueux, Aquitaine, France, 24019
2
Rennes University Hospital
Rennes, Britanny, France, 35033