Status:
COMPLETED
A Study to Compare the Effects of Different Sized Particles on Cells in the Nose
Lead Sponsor:
University of California, Los Angeles
Collaborating Sponsors:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Hypersensitivity, Immediate
Atopic Hypersensitivity
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The goal of this study is to see how the type and size of particles found in air pollution affects inflammation in the nose in people who are skin test positive to at least one allergen. It has been o...
Detailed Description
Cough, bronchitis, asthma, and chronic obstructive pulmonary disease are all associated with elevated pollution particle levels. Researchers believe that particulate pollutants can exacerbate allergy ...
Eligibility Criteria
Inclusion
- Previously determined high inflammatory responders to Diesel Exhaust Particles
- Previously determined atopy as demonstrated by allergy skin testing
- Asymptomatic on day of challenge.
Exclusion
- History of lung problems (including asthma), bleeding, neuromuscular, liver, kidney or heart disorders.
- History of anaphylaxis.
- Recent upper respiratory infection (less than 4 weeks prior to study) or other active infection.
- Active smoker or smoker in the past 2 years.
- Treatment with topical nasal steroids (\< 1 month), systemic steroids (\<1 month), oral antihistamines (\< 1 week) prior to any nasal challenge.
- Use of leukotriene receptor antagonist (\< 1 month ) prior to any nasal challenge
- Intranasal antihistamine or cromolyn use \< 1 week prior to any nasal challenge .
- History of treatment with allergy immunotherapy.
- Inability to perform nasal lavage.
- Inability to give written informed consent
- Pregnancy
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT01257191
Start Date
April 1 2010
End Date
January 1 2012
Last Update
January 11 2017
Active Locations (1)
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1
University of California, Los Angeles
Los Angeles, California, United States, 90095