Status:
COMPLETED
Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery
Lead Sponsor:
Centre hospitalier de l'Université de Montréal (CHUM)
Conditions:
Neurosurgery
Orthopedic Surgery
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Spinal surgery may be associated with substantial blood loss which often requires erythrocyte transfusion. Transfusion of red blood cells (RBC) is not free of adverse events and has been associated wi...
Detailed Description
Administration of study drug The administration of tranexamic acid/placebo will start following the induction of general anesthesia. A bolus dose will be given intravenously over 30 minutes followed ...
Eligibility Criteria
Inclusion
- Patients aged 18 to 85 years
- Patients undergoing spinal surgery with expected significant blood loss
- American Society of Anesthesiologists physical status(ASA) I to III inclusive
Exclusion
- Allergy to tranexamic acid
- Epilepsy
- Minimally invasive surgery
- Unwillingness to receive blood transfusion
- Known coagulopathy/hepatic disease
- Previous thromboembolic events
- Pregnancy
- Renal impairment
Key Trial Info
Start Date :
April 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT01258010
Start Date
April 1 2011
End Date
April 1 2014
Last Update
May 1 2014
Active Locations (1)
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1
Centre Hospitalier de l'Université de Montréal-Hôpital Notre-Dame
Montreal, Quebec, Canada, H2L 4M1