Status:
COMPLETED
Mother Daughter Bone Microarchitecture
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Bone Fragility
Eligibility:
FEMALE
20+ years
Brief Summary
The aim of this study is to analyze the hereditary determinism of bone microarchitecture measured at the distal radius and distal tibia from a case control-study of mother-daughter pairs.
Detailed Description
Many factors influence the risk of osteoporosis but one of the most important is a positive family history, emphasizing the importance of genetics in the pathogenesis of osteoporosis. Till now, most g...
Eligibility Criteria
Inclusion
- Case mothers: postmenopausal women who have at least one bone fragility fracture confirmed by radiological examination or by a surgical report. Fragility fracture is a fracture that occurs as a result of a fall from standing height or less. Fractures of the skull, fingers and toes will be excluded.
- Control mothers: menopausal women not having suffered from bone fragility fracture.
- Daughters: Women aged 20 and older (postmenopausal or not), biological daughters of participating mothers. Several daughters from the same mother may be included.
- Mothers and some daughters are recruited from the OFELY (Os des FEmmes de LYon) cohort or the FMC (Filière MédicoChirurgicale).
Exclusion
- Adoptive daughters
- Nonmenopausal mothers
Key Trial Info
Start Date :
May 4 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 29 2012
Estimated Enrollment :
1040 Patients enrolled
Trial Details
Trial ID
NCT01258036
Start Date
May 4 2010
End Date
February 29 2012
Last Update
November 18 2025
Active Locations (1)
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1
Unité Inserm 831, Pavillon F, Hôpital Edouard Herriot
Lyon, France, 69437