Status:
COMPLETED
Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril
Lead Sponsor:
Scripps Translational Science Institute
Conditions:
Hypertension, Grade 1
Hypertension Treatment
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this trial is to evaluate if an objective clinical decision of anti-hypertensive therapy can be made using an N-of-1 (single patient) trial design.
Detailed Description
Personalized medicine involves choosing the optimal treatment for a patient based on data gathered by the physician that is specific to that individual. The N-of-1 or single patient trial is a study d...
Eligibility Criteria
Inclusion
- Diagnosis of Grade 1 Hypertension
- Treatment naïve
- GFR \> 60 within previous 3 months
- Urinary microalbumin level normal during previous 3 months
Exclusion
- Pregnancy (Fetal morbidity and mortality may occur with the use of ACE inhibitors.)
- Uncontrolled Hyperthyroidism
- Sleep Apnea
- Primary Aldosteronism
- Renovascular Disease
- Cushing's Syndrome or steroid therapy
- No evidence of end organ damage
- EKG with evidence of LVH within previous 3 months
- Collagen Vascular Disease
- Current Smoker
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT01258764
Start Date
November 1 2010
End Date
March 1 2014
Last Update
May 20 2015
Active Locations (1)
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1
Scripps Clinic
La Jolla, California, United States, 92037