Status:
UNKNOWN
Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Hip Arthroplasty
Lead Sponsor:
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Conditions:
Hip Replacement
Postoperative Hemorrhage
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Tranexamic acid has been shown to reduce postoperative blood losses and transfusion requirements in a number of types of surgery. Most trials in orthopedic surgery have been conducted intravenously in...
Eligibility Criteria
Inclusion
- Patient who are to undergo elective total hip arthroplasty.
- Must be primary arthroplasty.
- Must be single-side arthroplasty.
- Must be older than 18 years.
Exclusion
- Cemented arthroplasty.
- Patients with a platelet count less than 100, 000/mm3 or history of thrombocytopenia .
- Patients with known coagulopathy (APTT or PT outside normal range pre-operatively).
- Patients who have a past medical history of thrombi-embolism at any time.
- Patients with anemia (hemoglobin levels less than 8 mg/dl or hematocrit \<24%).
- Patients with documented DVT or PE at screening or in past three months.
- Patients having known hypersensitivity to tranexamic acid or any other. constituent of the product.
- Patients with any associated major illness (e.g., severe cardiac \[New York Heart Association Class III or IV\] or respiratory disease).
- Anticoagulants (other than LMWH or heparin in prophylactic doses to prevent deep vein thrombosis), direct thrombin inhibitors or thrombolytic therapy administered or completed within last week.
- Jehovah's Witnesses, or any other group of patients with ethical objections to receiving blood products.
Key Trial Info
Start Date :
December 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01260818
Start Date
December 1 2010
Last Update
December 1 2011
Active Locations (1)
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1
the First Affiliated Hospital of Guangzhou TCM University
Guangzhou, Guangdong, China, 510405