Status:
COMPLETED
Mechanisms of Mitochondrial Defects in Gulf War Syndrome
Lead Sponsor:
Medical Neurogenetics, LLC
Collaborating Sponsors:
United States Department of Defense
Conditions:
Gulf War Syndrome
Mitochondrial Disease
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of the study is to investigate possible causes for Gulf War Syndrome. Gulf War Syndrome is associated with increased incidences of amyotrophic lateral sclerosis (Lou Gehrig's Disease), pai...
Eligibility Criteria
Inclusion
- Short-term memory loss or a severe inability to concentrate that affects work, school or other normal activities
- Muscle Pain, myalgias
- Pain without redness or swelling in a number of joints
- Intense or changing patterns of headaches
- Unrefreshing sleep
- After any exertion, weariness that lasts for more than a day
Exclusion
- Organ failure (e.g. emphysema, cirrhosis, cardiac failure, chronic renal failure)
- Chronic infections (e.g. HIV/AIDS, hepatitis B or C)
- Rheumatic and chronic inflammatory diseases (e.g. systemic lupus erythematosis, Sjogren's syndrome, rheumatoid arthritis, inflammatory bowel disease, chronic pancreatitis.)
- Major neurologic diseases (e.g. multiple sclerosis, neuromuscular diseases, epilepsy or other disease requiring ongoing medication that could cause fatigue, stroke, head injury with residual neurologic deficits)
- Diseases requiring systemic treatment (e.g. organ or bone marrow transplantation; systemic chemotherapy; radiation of brain, thorax, abdomen, or pelvis)
- Major endocrine diseases (e.g. hypopituitarism, adrenal insufficiency)
- Myocardial infarction, heart failure
- Morbid obesity (body mass index \>40)
- Permanent psychiatric exclusions: Lifetime diagnoses of bipolar affective disorders, schizophrenia or any subtype, delusional disorders of any subtype, dementias of any subtype, organic brain disorders, and alcohol or substance abuse within 2 years before onset of the fatiguing illness.
- History of allergic reaction to lidocaine
- History of keloid formation with skin incisions.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT01264471
Start Date
May 1 2009
End Date
June 1 2013
Last Update
April 13 2015
Active Locations (1)
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1
Medical Neurogenetics, LLC
Atlanta, Georgia, United States, 30342