Status:
COMPLETED
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary
Lead Sponsor:
Columbia University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
50-79 years
Brief Summary
The Multi-Ethnic Study of Atherosclerosis (MESA) - Chronic Obstructive Pulmonary Disease (COPD) Study aims to characterize the pulmonary vascular changes and their biology in early COPD using imaging,...
Detailed Description
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death in the US and will soon replace stroke as the third leading cause. Translation of promising biological hypotheses of C...
Eligibility Criteria
Inclusion
- age 50-79 years at time of enrollment
- ever smokers (10 or more pack-years)
- participation in MESA or EMCAP studies
Exclusion
- clinical cardiovascular disease (left congestive heart failure (CHF), valve disease, coronary artery disease (CAD), stroke, or congenital heart disease),
- asthma, pulmonary embolism or lung disease other than COPD,
- weight \> 300 lbs,
- chronic renal insufficiency (\[estimated glomerular filtration rate (eGFR)\] \< 45 mL/min/1.73 m2),
- atrial fibrillation, and
- contraindications to magnetic resonance imagine (MRI), gadolinium, albuterol or spirometry testing.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 30 2018
Estimated Enrollment :
359 Patients enrolled
Trial Details
Trial ID
NCT01397721
Start Date
May 1 2009
End Date
April 30 2018
Last Update
July 24 2024
Active Locations (4)
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1
UCLA Research Center
Alhambra, California, United States, 91801
2
Northwestern University Medical School
Chicago, Illinois, United States, 60611
3
Johns Hopkins University
Baltimore, Maryland, United States, 21205
4
Columbia University
New York, New York, United States, 10032