Status:
COMPLETED
Prediction of ARrhythmic Events With Positron Emission Tomography
Lead Sponsor:
State University of New York at Buffalo
Conditions:
Ischemic Cardiomyopathy
Hibernating Myocardium
Eligibility:
All Genders
18+ years
Brief Summary
The hypothesis of PAREPET is that hibernating myocardium (viable myocardium with reduced resting flow) and/or viable but denervated myocardium can predict the risk of sudden death in subjects with isc...
Detailed Description
Currently available electrophysiological approaches are limited in their ability to identify the majority of patients with CAD and LV dysfunction that succumb to sudden cardiac death (SCD). Half of th...
Eligibility Criteria
Inclusion
- LV EF ≤35% (by nuclear imaging, cardiac catheterization or echocardiography)
- Coronary artery disease documented by cardiac catheterization, a history of definite myocardial infarction, or reversible ischemia on nuclear imaging
- New York State Heart Association functional Class I-III heart failure
- Not a candidate for surgical or percutaneous coronary revascularization at the time of enrollment
Exclusion
- History of resuscitated sudden cardiac death, sustained ventricular tachycardia, appropriate implantable cardiac defibrillator (ICD) discharge, or unexplained syncope
- Myocardial infarction within 30 days
- Coronary artery bypass grafting within 1 year
- Percutaneous intervention within 3 months
- Claustrophobia or physical limitation that would preclude PET scanning
- Pregnancy
- Tricyclic antidepressant drug therapy
- Comorbidities that would be expected to result in noncardiac death within 2 years
- Inability to provide informed consent
Key Trial Info
Start Date :
July 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
257 Patients enrolled
Trial Details
Trial ID
NCT01400334
Start Date
July 1 2004
End Date
December 1 2012
Last Update
October 12 2020
Active Locations (1)
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1
SUNYBuffalo
Buffalo, New York, United States, 14214