Status:
COMPLETED
Long-term Phentermine Pharmacotherapy: An Investigation for Symptoms of Dependence, Cravings, or Withdrawal
Lead Sponsor:
Center for Weight Management, California
Collaborating Sponsors:
American Society of Bariatric Physicians
Conditions:
Obesity
Phentermine Withdrawal
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Phentermine, an amphetamine congener, is the most widely used anti-obesity drug in the U.S. Although phentermine is the agent-of-choice among physicians specializing in obesity treatment, the use of t...
Eligibility Criteria
Inclusion
- Aged 18 years or older.
- Duration of phentermine treatment
- For LPT patients, on phentermine pharmacotherapy consecutively for 2 years or more and willing to take a drug holiday for 48 to 72 hours.
- LPT Patients who have taken drug holidays on their own during the most recent 2 years may be included provided there has not been a holiday in the 90 days prior to matriculation in this study.
- For APT patients, on phentermine pharmacotherapy for 7 to 14 days at 37.5 mg/day or less.
Exclusion
- Patients with confirmed Axis I psychiatric conditions including depression, ADHD, SAD, bipolar disorder, substance abuse disorders (except caffeine and nicotine) and patients taking drugs for any of these conditions, including anti-depressant drugs, drugs for ADHD and lithium.
- Patients who were taking phentermine in combination with any other anti-obesity drug.
- Patients who are taking medications such as beta-blockers, which may modulate the stimulant effect of phentermine.
- Pregnant patients, nursing mothers, patients with uncontrolled hypertension, hyperthyroidism, severe cardiovascular disease, glaucoma, and known hypersensitivity to phentermine -
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
269 Patients enrolled
Trial Details
Trial ID
NCT01402674
Start Date
August 1 2011
End Date
November 1 2012
Last Update
January 28 2013
Active Locations (2)
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1
Center for Weight Management
Roseville, California, United States, 95661
2
Center for Weight Management
Sacramento, California, United States, 95816