Status:
UNKNOWN
Innovative Biomarkers in Alzheimer's Disease and Frontotemporal Dementia (FTD): Preventative and Personalized
Lead Sponsor:
Rambam Health Care Campus
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
45-80 years
Brief Summary
Tau pathology and tangles have been associated with cognitive dysfunction causing neurodegeneration. AD, the most abundant tauopathy is characterized by amyloid plaques and tau tangles. An abundance o...
Detailed Description
Assessing biomarkers in Alzheimer's disease and frontotemporal dementia 1. Specific Aims To enhance the field of biomarker recognition and facilitate preventative and personalized medicine we are...
Eligibility Criteria
Inclusion
- Minimal cognitive impairment (MCI) and Alzheimer's disease (AD) patients, men and women, age 45-80 will be asked to participate in the present study.
- MCI will be diagnosed when on cognitive evaluation the patients will score \<1.5 SD on memory tests and will not be demented. AD will be diagnosed according to NINCDS-ADRDA research criteria. Patients will be stratified by age and cognitive (dementia) status. Disease severity for AD: mild to moderate (MMSE \>16) AD.
- Frontotemporal dementia: patients with a clinical diagnosis of frontotemporal dementia \[behavioral variants (bv)FTD, progressive nonfluent aphasia (PNFA), or semantic dementia\] and the related syndromes corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) will be included.
- Inclusion criteria (controls): men and women, ages 45-80, willing to participate in the study and donate a blood samples.
Exclusion
- (patients and controls):
- Subjects unable/unwilling to sign an informed consent.
- Patients with associated medical condition: alcoholism, immune diseases and end stage medical conditions.
Key Trial Info
Start Date :
July 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2014
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT01403519
Start Date
July 1 2011
End Date
January 1 2014
Last Update
July 27 2011
Active Locations (1)
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1
Rambam Hospital
Haifa, Israel, 31096