Status:
COMPLETED
Personal Genomics for Preventive Cardiology
Lead Sponsor:
Stanford University
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to see if providing information to a person on their inherited (genetic) risk of cardiovascular disease (CVD) helps to motivate that person to change their diet, lifestyle...
Detailed Description
Genome wide association studies (GWAS) have identified over 1000 disease associated SNPs, including many related to cardiovascular disease (CVD). Associations have been found for most traditional risk...
Eligibility Criteria
Inclusion
- Adults age \> 18
- Patient seeking cardiovascular risk evaluation
- At intermediate (6-20%) or high risk (\> 20%) over 10 years of CAD as defined by Framingham 10 year risk score AND/OR at \> 20% risk of CAD over 30 years using the Framingham 30 year risk calculator
- The genetic risk factors have been evaluated predominantly in white/European subjects. However, there is considerable overlap in the genetic architecture of South Asians and Hispanic/Latino populations. Therefore, we will limit our initial studies to these three race/ethnicity groups.
Exclusion
- History of myocardial infarction, angina, stroke, peripheral arterial disease, PCI, or CABG
- Already on lipid lowering therapy
- Anticipated survival \<1 year (e.g. metastatic cancer)
- Serious conditions that would limit ability to adhere to recommendations (inability to take statins, exercise)
- Already had genetic testing
- Concurrent enrollment in another clinical trial
- Pregnant or breastfeeding
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2017
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01406808
Start Date
August 1 2011
End Date
August 1 2017
Last Update
October 5 2017
Active Locations (1)
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1
Stanford Medical Center
Stanford, California, United States, 94305