Status:
TERMINATED
Droperidol Versus Metoclopramide + Diphenhydramine for the Treatment of Primary Headaches
Lead Sponsor:
University of Iowa
Conditions:
Primary Headaches (Includes Migraines, Tension, Cluster Headaches)
Eligibility:
All Genders
18-64 years
Phase:
NA
Brief Summary
The purpose of this study is to determine if droperidol is equally as effective as metoclopramide for treatment of primary headaches in the Emergency Department.
Eligibility Criteria
Inclusion
- 18 years old to 65 years old, diagnosis of primary headache
Exclusion
- Allergy to study medications, pregnant, breast-feeding, prisoners, non-english speaking, not eligible to receive droperidol based on ED protocol (see below), patients in whom head trauma, infection, vascular disorders, and disorders of facial or cranial structures are suspected
- ED Droperidol Protocol
- Droperidol must NOT be used in patients with any of the following:
- Known or suspected QT prolongation, including congenital long QT syndrome
- Cardiac Disease \[cardiomyopathy, congestive heart failure, hypertension, ischemic heart disease, myocardial infarction, bradycardia (\< 50 bpm)\]
- History of the following:
- Renal failure
- Cerebrovascular disease
- Diabetes or hypoglycemia
- Alcoholism/alcohol abuse
- Pituitary insufficiency
- Hypothyroidism
- Hypothermia
- Anorexia
- Advanced age (\>65 yrs)
- Use of the following medications: digoxin, benzodiazepine, diuretics, IV opiates, or other medications known to prolong the QTc interval.
Key Trial Info
Start Date :
July 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT01406860
Start Date
July 1 2011
End Date
July 1 2012
Last Update
December 5 2017
Active Locations (1)
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1
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242