Status:
COMPLETED
Diagnostic Value of sTREM-1 and PCT Level as Well as CPIS Score for Ventilator-Associated Pneumonia Among ICU Sepsis Patients
Lead Sponsor:
Chinese PLA General Hospital
Conditions:
Sepsis
Ventilator-Associated Pneumonia
Eligibility:
All Genders
18+ years
Brief Summary
Aims: to explore the value of TREM-1 (triggering receptor expressed on myeloid cells-1) ,PCT(Procalcitonin), as well as CPIS (clinical pulmonary infection score) in the diagnostic and prognostic asses...
Eligibility Criteria
Inclusion
- （1）Male and female aged 18 years old and over;
- （2）Fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 °C or lower than 36 °C (b)respiratory rate above 20/min, or PCO2 below 32 mmHg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands.（3）Clinically suspected infection; （4）Fulfilled criteria of VAP diagnosis(a) after 48-72h endotracheal intubation, X-ray film displays new or progressive infiltrating focus; (b)The patient is in two of the following conditions: a. fever (temperature \>38 ℃ or higher than basal temperature; b. peripheral WBC count≥10×10∧9/L，or \<4×10∧9/L; c. appearance or increase of purulent respiratory tract secretion. Besides the diagnostic norms above, it is suggested that lower respiratory tract secretions be collected under the bronchoscope and half-quantitative etiological culture be carried out through the medium of BALF samples (diagnostic threshold value:104cfu/mL ).
Exclusion
- (1) were under 18 years of age;
- (2) had contracted VAP upon ICU admission or in less than 48h after being admitted;
- (3) were suffering from acquired immunodeficiency syndrome;
- (4)were suffering from polymorphonuclear granulocyte counts (\< 500 μL-1); - (5) died within 24h after being taken into the ICU, or refused to get involved in the study, or gave up treatment during the period of observation
Key Trial Info
Start Date :
September 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT01406951
Start Date
September 1 2009
End Date
March 1 2011
Last Update
August 1 2011
Active Locations (1)
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1
Chinese PLA General Hospital
Beijing, Beijing Municipality, China, 100853