Status:
COMPLETED
Male Infertility Related With Post Infection Inflammatory Syndrome
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
URC-CIC Paris Descartes Necker Cochin
Conditions:
Male Infertility
Leukopenia
Eligibility:
MALE
18+ years
Phase:
NA
Brief Summary
BACKGROUND: One couple out of 6 consults for infertility during their sexual life. In 60% of cases a male factor is associated or is the main infertility factor. Inflammatory Syndrome (IS), characteri...
Detailed Description
Progress of research. Timeframe Search * Duration of inclusions: 30 months * Duration of patient follow-up: 7 months * Total duration of the study: 37 months Within the framework of their coverage in...
Eligibility Criteria
Inclusion
- Inclusion criteria :
- Man over 18 years old
- Patient presenting a leukocytospermia ≥ 0,5\*106 /ml or an elastase ≥ 500ng/ml
- No infection
- Signed informed consent
- Exclusion criteria :
- Patient having less of 106 /ml of sperm cells in the ejaculate
- Patients with diabetes or receiving treatment for diabetes
- Patients already taking anti-inflammatory drugs
- Patients with ongoing anticoagulant therapy
- Patients with history of allergy to anti-inflammatory drug
- Patients with a history of peptic ulcers
- Patient with history of cardiovascular disease (hypertension, cardiac arrhythmia, ...)
- Patients with psychological disorders
- Patient with an infectious condition except for specified indications of Prednisone
- Patients with some evolutional viruses(including hepatitis, herpes, chickenpox, shingles)
- Patient is in a psychotic state still not controlled by treatment
- Patient receiving a live vaccine
- Patients with hypersensitivity to any component of Prednisone
- Patient not affiliated with a social security system
- Criteria for randomization
- \- Patient meeting all inclusion criteria and none of exclusion, and having a 8OH desoxy Guanosine increased ≥ 35%.
Exclusion
Key Trial Info
Start Date :
March 2 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 14 2015
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01407484
Start Date
March 2 2011
End Date
May 14 2015
Last Update
November 20 2025
Active Locations (1)
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1
Cochin Hospital
Paris, France, 75014