Status:

COMPLETED

Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients

Lead Sponsor:

RWTH Aachen University

Conditions:

CKD 5D, Hemodialysis

Eligibility:

All Genders

18+ years

Phase:

PHASE3

Brief Summary

Vascular calcification (VC) is a predictor of cardiovascular morbidity and mortality. Hemodialysis (HD) patients suffer from severe vascular calcifications. Matrix Gla protein (MGP) is a central calci...

Eligibility Criteria

Inclusion

  • \> 18 years of age
  • minimum of 3 months of hemodialysis
  • written consent

Exclusion

  • chronic or acute bowel disease
  • soy bean allergy
  • active Vitamin K Supplementation
  • oral anticoagulation with vitamin K Antagonists (coumarins)
  • systemic therapy using steroids
  • positive history for thrombosis or embolism
  • pregnancy

Key Trial Info

Start Date :

January 1 2008

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

July 1 2009

Estimated Enrollment :

53 Patients enrolled

Trial Details

Trial ID

NCT01407601

Start Date

January 1 2008

End Date

July 1 2009

Last Update

August 2 2011

Active Locations (3)

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Page 1 of 1 (3 locations)

1

KfH Dialysis Unit Aachen

Aachen, North Rhine-Westphalia, Germany, 52074

2

University Hospital of the RWTH Aachen

Aachen, North Rhine-Westphalia, Germany, 52074

3

Dialysis Unit Erkelenz

Erkelenz, North Rhine-Westphalia, Germany, 41812