Status:
TERMINATED
A Dose Response Effect of Atomoxetine to the Acute Effects of Alcohol
Lead Sponsor:
University of Colorado, Boulder
Collaborating Sponsors:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Center for Research Resources (NCRR)
Conditions:
Alcohol Craving
Mood Changes
Eligibility:
All Genders
21-45 years
Phase:
PHASE1
Brief Summary
This two-stage study will examine the effects of a 5 day course of atomoxetine (placebo, 40, 60 or 80 mg/day; Strattera) (a selective NE transporter (NET) inhibitor) on alcohol-elicited craving and se...
Eligibility Criteria
Inclusion
- Inclusion Criterion:
- Males and females age 21 to 35, as verified upon the presentation of a valid driver's license;
- Must drink alcohol at least twice a week and have a minimum of 3 drinks per occasion (2 for women);
- Must score 8 or higher on the Alcohol Use Disorders Identification Test (AUDIT; Babor et al., 1992). The AUDIT is a screening instrument used to identify persons whose alcohol consumption is characterized by moderate to heavy drinking;
- No history of alcohol treatment or desire for treatment;
- Not currently take medications that are contraindicated for concurrent use with alcohol;
- Female subjects must not be pregnant, as indicated by a pregnancy test that will be conducted immediately prior dispensing of medication.
- Exclusion Criterion:
- Subjects who have hypertension, tachycardia, cardiovascular disease, hepatic or renal impairment, pregnant or who are currently using MAO inhibitors, Albuterol or other pressor agents will be excluded from this study.
Exclusion
Key Trial Info
Start Date :
June 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT01408589
Start Date
June 1 2005
End Date
December 1 2007
Last Update
August 3 2011
Active Locations (1)
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1
GCRC, University of Colorado Boulder
Boulder, Colorado, United States, 80309