Status:
COMPLETED
Effectiveness of Deep Transcranial Magnetic Stimulation in Depression
Lead Sponsor:
Douglas Mental Health University Institute
Collaborating Sponsors:
Brainsway
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
PHASE3
Brief Summary
We intend to investigate whether deep transcranial magnetic stimulation (DTMS), a novel brain stimulation technique, is effective for treating major depression. We hypothesize that 4 weeks of DTMS wil...
Detailed Description
The aim of this pilot study is to assess, naturalistically, the effectiveness of deep transcranial magnetic stimulation (DTMS) in a sample of subjects with treatment-resistant depression. To do this, ...
Eligibility Criteria
Inclusion
- Presence of a current major depressive disorder (according to the DSM-IV-TR) that has not improved after ≥ 1 but ≤ 5 adequate antidepressant trial(s) in the current episode
- Baseline score ≥ 15 on the QIDS-C
- Stable medication regimen (\> 4 weeks)
Exclusion
- Psychotic features in the current episode
- Lifetime history of psychotic disorders and/or bipolar I or II disorders
- Substance or alcohol abuse/dependence in the past 6 months
- Lifetime history of a major neurological disease (e.g., Parkinson's, stroke)
- Uncontrolled medical disease (e.g., cardiovascular, renal)
- Pregnancy and/or lactation
- Presence of a specific contraindication for DTMS (e.g., personal history of epilepsy, metallic head implant)
- Hearing loss
- Personal history of abnormal brain MRI findings
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT01409304
Start Date
October 1 2011
End Date
December 1 2012
Last Update
January 18 2013
Active Locations (1)
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1
Neuromodulation Research Clinic, Douglas Mental Health University Institute
Montreal, Quebec, Canada, H4H1R3