Status:
COMPLETED
Neural Predictors and Longitudinal Neural Correlates of Deep Transcranial Magnetic Stimulation for Treating Major Depression
Lead Sponsor:
Douglas Mental Health University Institute
Collaborating Sponsors:
Brainsway
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
25-50 years
Phase:
PHASE2
PHASE3
Brief Summary
Standard high frequency repetitive transcranial magnetic stimulation (HF-TMS) is a noninvasive method to activate or de-activate neurons in superficial regions of the brain through the induction of we...
Eligibility Criteria
Inclusion
- Presence of a current major depressive disorder (according to the Diagnostic and Statistical Manual, Fourth Edition, Text Revision \[DSM-IV-TR\]) that has not improved after ≥ 1 but ≤ 3 adequate antidepressant trial(s) in the current episode
- Baseline score ≥ 21 on the HAM-D21
- Stable medication regimen (\> 4 weeks)
Exclusion
- Psychotic features in the current episode
- Lifetime history of psychotic disorders and/or bipolar I or II disorders
- Substance or alcohol abuse/dependence in the past 6 months
- Lifetime history of a major neurological disease (e.g., Parkinson's, stroke)
- Uncontrolled medical disease (e.g., cardiovascular, renal)
- Pregnancy and/or lactation
- Presence of a specific contraindication for DTMS/rTMS/MRI (e.g., personal history of epilepsy, metallic head implant, cardiac pacemaker)
- Personal history of abnormal brain MRI findings
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01409317
Start Date
April 1 2013
End Date
January 1 2015
Last Update
May 28 2015
Active Locations (1)
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1
Neuromodulation Research Clinic, Douglas Mental Health University Institute
Montreal, Quebec, Canada, H4H1R3