Status:
COMPLETED
Cilostazol Augmentation Study in Dementia
Lead Sponsor:
Seoul National University Hospital
Collaborating Sponsors:
Korea OIAA
Conditions:
Alzheimer's Dementia
Eligibility:
All Genders
60+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to examine the effects of cilostazol augmentation in mild to moderate Alzheimer disease patients with subcortical white matter hyperintensities (WMHI) treated by donepezil...
Eligibility Criteria
Inclusion
- Men/women over sixty years old
- Patients with slight and moderate dementia (MMSE score is over 10 under 26.)
- Patients with probable Alzheimer's disease according to the standard of NINCDS-ADRDA
- Patients accompanied with WMHI on Brain MRI (Fazeka's scale 1\~3)
Exclusion
- Those who do not agree to the test in a written form
- Patients who accompany other diseases except cerebral atrophy or change of subcortical white matter due to Alzheimer's disease on brain MRI
- Patients who should not use Cilostazol (① patients with bleeding tendency ② patients with congestive heart failure ③ patients who have a medical history of hypersensitivity to this medicine or constituent of this medicine ④ those who use anticoagulant and clot buster)
- Patients who suffer from nerve diseases or mental diseases which have influence on cognitive function except Alzheimer's disease (for example, schizophrenia, severe depression, mental retardation and etc.)
- Patients who are suspected to have a personal history of drug addiction or alcoholism within recent 10 years
- Patients who have severe problems in eye sight or hearing so that it is impossible to conduct the test smoothly
- Patients who the researchers think are inappropriate for taking part in the test
Key Trial Info
Start Date :
May 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT01409564
Start Date
May 1 2010
End Date
July 1 2013
Last Update
May 13 2014
Active Locations (1)
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1
SMG-SNU Boramae Medical Center
Seoul, South Korea, 156-707