Status:
ACTIVE_NOT_RECRUITING
Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Groupe Hospitalier Pitie-Salpetriere
Conditions:
Turner Syndrome
Ovarian Insufficiency
Eligibility:
FEMALE
1-25 years
Phase:
NA
Brief Summary
Ovarian insufficiency is common in Turner syndrome related to premature and rapid follicular apoptosis and spontaneous pregnancies are rare in this population. Ovarian cryopreservation has been used i...
Detailed Description
Turner syndrome (TS) is characterized by the absence of all or part of a normal second X chromosome and occurs in about 1/2,500 live-born girls. Spontaneous fertility is rare among patients with TS re...
Eligibility Criteria
Inclusion
- Inclusion criteria :
- girls aged from 1 to 25 years included,
- with Turner syndrome or mosaic
- patients aged more than 18 will only have ovarian insufficiency dated less than 5 years
- without any severe disease, particularly of cardiovascular type
- whose agreement to participate to the study has been signed by the parents
- whose agreement to participate to the study has been signed by majority age patient
- Exclusion criteria :
- girls aged less than one year and over 25 years old
- if any surgery would be contra-indicated
- ovary alone presence
- Well-known infection by HIV, and/or HBV, and/or HCV and/or syphilis TPHA VDRL
- No social coverage affiliate
Exclusion
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2031
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT01410045
Start Date
January 1 2011
End Date
February 1 2031
Last Update
May 17 2021
Active Locations (1)
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1
Hopital Bicêtre
Le Kremlin-Bicêtre, France, 94275