Status:
COMPLETED
Adipokines in Obese Adolescents With Insulin Resistance
Lead Sponsor:
Hospital Regional de Alta Especialidad del Bajio
Collaborating Sponsors:
Hospital Infantil de Mexico Federico Gomez
Conditions:
Obesity
Eligibility:
All Genders
9-18 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alph...
Detailed Description
The increased prevalence of obesity in pediatric patients is a public health problem particularly because of the difficulties involved with changing lifestyles. Current studies of obese children and a...
Eligibility Criteria
Inclusion
- Obesity defined as Body Mass Index (BMI) ≥ percentile 95
- Tanner stage ≥ 2
- Insulin resistance defined as Basal insulin \> 15 µU/mL or Homeostasis Model Assessment index (HOMA) \> 4.5
- Patients' parents signed written consents when they and their adolescent children agreed to enroll
Exclusion
- Glucose intolerance
- Diabetes mellitus (type 1 or 2)
- Anemia (Hb \< 10 g/dL)
- Plasma creatinine \> 1.4 mg/dL
- Abnormal hepatic function
- Any associated Disease (Pulmonary, Infection, Autoimmune Disease)
- History of lactic acidosis
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT01410604
Start Date
January 1 2007
End Date
March 1 2010
Last Update
April 27 2012
Active Locations (2)
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1
Hospital Regional de Alta Especialidad del Bajío
León, Guanajuato, Mexico, 37670
2
Hospital Infantil de México Federico Gómez
Mexico City, Mexico City, Mexico, 06720