Status:
UNKNOWN
Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population
Lead Sponsor:
Ottawa Hospital Research Institute
Conditions:
Malignant Pleural Effusion
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Patients with cancer may experience problems with their breathing due to a fluid accumulation around their lungs called malignant pleural effusion (MPE). This fluid can be drained but draining may not...
Detailed Description
Malignant pleural effusions (MPE) occur in 25 - 50% of malignancies, represent advanced disease and carry with it significant morbidity. It is estimated that 75% of malignant effusions are symptomatic...
Eligibility Criteria
Inclusion
- Presence of symptomatic and moderate sized (\>1/3 of hemithorax) MPE
- Persistent malignant pleural effusion that is free-flowing
- Symptomatic improvement after therapeutic thoracentesis
- Life expectancy of at least three months (duration of study follow-up)
- 90% radiographic apposition of parietal and visceral pleura
- Residence within 30 minute radius from The Ottawa Hospital
Exclusion
- Previous lobectomy or pneumonectomy on affected side
- Multiple loculations
- Trapped or entrapped lung
- Untreated pleural infection
- Abnormal coagulation profile (INR\>1.5 and / or platelet count \<50 x 10\*9/L)
- Planned intrapleural chemotherapy (however participants may receive concomitant systemic chemotherapy, mediastinal radiation therapy or steroids)
- Life expectancy less than 3 months
- Multiple co-morbidities limiting out-patient management of pleural effusion
- Tetracycline / Doxycycline allergy
Key Trial Info
Start Date :
June 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01411202
Start Date
June 1 2011
End Date
December 31 2021
Last Update
September 25 2020
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Ottawa Hospital
Ottawa, Ontario, Canada, K1H 8L6
2
The Ottawa Hospital
Ottawa, Ontario, Canada, K1H8L6