Status:
COMPLETED
The Effect of Intravenous Nutrition in Patients Undergoing Abdominal Surgery
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Conditions:
Postoperative Protein Catabolism
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Loss of muscle protein and mass are the main causes of fatigue after bowel surgery which may result in a longer hospital stay and a higher rate of complications. This problem is especially important f...
Detailed Description
1. Goals The overall goal of perioperative nutrition support is to abolish protein wasting and to promote anabolic processes by directing amino acids into protein synthesis rather than oxidation. Prot...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists \<3
- colorectal surgery for non-metastatic colorectal carcinoma including right and left hemicolectomy, transverse, subtotal and total colectomy, sigmoid resection
- ability to give informed consent
Exclusion
- signs of severe malnutrition or obesity: body mass index \<18 or \>25 \>10% involuntary body weight loss over the preceding 6 months serum albumin \<21 g/L
- significant cardiorespiratory, hepatic, renal and neurological disease
- ingestion of drugs known to affect protein, glucose and lipid metabolism (for example steroids)
- musculoskeletal or neuromuscular disease
- severe anemia (hemoglobin \<10 g/dL)
- pregnancy
- history of severe sciatica or back surgery or other conditions which
- contraindicate the use of epidural catheters
Key Trial Info
Start Date :
November 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01414946
Start Date
November 1 2009
End Date
July 1 2011
Last Update
August 11 2011
Active Locations (1)
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1
Royal Victoria Hospital, McGill University Health Centre
Montreal, Quebec, Canada, H3A 1A1