Status:
TERMINATED
Use of Biomarkers to Optimize Fluid Dosing,CRRT Initiation and Discontinuation in Pediatric ICU Patients With AKI
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Conditions:
Acute Kidney Injury
Fluid Overload
Eligibility:
All Genders
1-25 years
Phase:
NA
Brief Summary
Acute Kidney Injury (AKI) is a common clinical problem defined by an abrupt (\< 48 hour) increase in serum creatinine (SCr) resulting from an injury or insult that causes a functional or structural ch...
Detailed Description
The specific aims of this proposal are: 1. Determine if NGAL (POC plasma and confirmatory urine) concentrations can predict which critically ill children will ultimately develop significant (\>10%) p...
Eligibility Criteria
Inclusion
- Age 1-25 years old
- Must weigh at least 20kg
- Receiving mechanical ventilation
- Receiving at least 1 vasoactive medication: dopamine (dose greater then 5 micrograms/kg/min), Dobutamine, Epinephrine, Norepinephrine or Vasopressin
Exclusion
- History of End Stage Renal Disease, on Dialysis
- Immediately post renal transplant
- Within 96 hours of Cardiopulmonary Bypass Surgery
- Weight less than 20 kg Patient with a DNR order, "do not escalate care" order, or life expectancy of less than 1 week.
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT01416298
Start Date
August 1 2011
End Date
December 1 2015
Last Update
September 20 2018
Active Locations (1)
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1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229