Status:
COMPLETED
Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Dutch Heart Foundation
Synvista Therapeutics, Inc
Conditions:
Cardiovascular Disease
Aging
Eligibility:
All Genders
65+ years
Phase:
PHASE2
PHASE3
Brief Summary
Healthy but sedentary aging leads to increased morbidity and mortality of cardiovascular disease. This is partly due to the accumulation of Advanced Glycation Endproducts (AGEs) and the stiffening of ...
Eligibility Criteria
Inclusion
- Healthy sedentary elderly
- Age 65 yrs and older
Exclusion
- Cardiovascular disease
- Cerebrovascular disease
- Changes on ECG indicating cardiomyopathy or ischemia
- No cardiovascular medication
- Diabetes Mellitus
- Hypercholesterolemia
- BMI \> 33 kg/m2
- Intensive exercise \> 1 hour a week
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT01417663
Start Date
November 1 2008
End Date
June 1 2011
Last Update
September 9 2013
Active Locations (1)
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1
Radboud University Nijmegen Medical Centre
Nijmegen, Netherlands, 6525EZ