Status:
UNKNOWN
Renal Sympathetic Modification in Patients With Chronic Renal Failure
Lead Sponsor:
The Second Affiliated Hospital of Chongqing Medical University
Collaborating Sponsors:
Jiangsu Provincial People's Hospital
Chongqing Medical University
Conditions:
Chronic Renal Failure
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The purpose of this study is to observe the incident of uremia and dialysis requirement after renal sympathetic modification using THERMOCOOL® catheter in patients with chronic renal failure, and eval...
Detailed Description
Chronic renal failure is serial clinical manifestations because of kidney damage. Previous studies found sympathetic nerves over activity in chronic renal failure patients. Traditional therapies inclu...
Eligibility Criteria
Inclusion
- ≥ 18 years old, and ≤ 75 years old of age
- at least three months history of definite kidney damage
- renal function of serum creatinine of \< 354umol/L, and/or creatinine clearance rate of ≥ 30ml/min, and/or estimated glomerular filtration rate of ≥ 45ml/min for recent 2-3 times evaluation. Besides, the value of creatinine clearance rate fluctuated no more than 30% in recent three months, and 15% in the following two weeks.
- urine microalbumin, and/or urine microalbumin/creatinine is abnormal, and/or quantity of 24 hrs urine protein suggests kidney damage.
- is competent and willing to provide written, informed consent to participate in this clinical study
Exclusion
- congenital renal diseases cause to chronic renal damage
- estimated glomerular filtration rate (eGFR) of \< 45mL/min
- taking medicine of glucocorticosteroids, non-steroid anti-inflammatory drugs (NSAIDs), or cytotoxic drugs at present
- value of 24 hrs urine protein is of \> 10g at least once in recent three months, or serum albumin of \< 25g/L
- has the history of renal restenosis or renal stents implantation
- has experienced AMI (old myocardial infarction is not excluded), unstable angina pectoris, cerebrovascular accidents, and alimentary tract hemorrhage within 3 months
- carcinoma patients
- patients with sick sinus syndrome
- pregnant women
- mental disorders
- patients that have allergy to contrast agent
- patients that do not go with follow-up
- others such as researcher considers it is not appropriate to be included into the study
Key Trial Info
Start Date :
August 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2020
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01418560
Start Date
August 1 2011
End Date
June 1 2020
Last Update
March 19 2019
Active Locations (1)
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1
2ndChongqingMU
Chongqing, Chongqing Municipality, China, 400010