Status:
COMPLETED
Pregabalin and Remifentanil - Analgesia and Ventilation
Lead Sponsor:
Oslo University Hospital
Conditions:
Pain
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
In this experimental study on healthy volunteers we explored the effect of pregabalin alone and in combination with remifentanil on acute experimental pain and ventilatory function.
Detailed Description
Pain during cold pressor test (CPT) was scored at all dose levels of remifentanil on a visual analogue scale (VAS 0-100 mm). Ventilatory function was measured by spirometry registering respiratory fre...
Eligibility Criteria
Inclusion
- Healthy volunteers,
- \> 18 yrs \< 55 yrs,
- negative pregnancy test
Exclusion
- Pregnancy,
- nursing,
- known heart-, lung- or liver disease,
- kidney failure/peptic ulcers,
- use of liver enzyme-inducing medications,
- known allergy against the medications used in the trial,
- use of psychotropic drugs, analgesics or alcohol used the last 24 hours before the trial,
- body weight \> 100 kg or 30% deviation from normal weight,
- participant in other studies during the last 2 months,
- individuals who do not master Norwegian language
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2012
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01419405
Start Date
December 1 2011
End Date
March 1 2012
Last Update
September 12 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Oslo Universitetssykehus, Rikshospitalet
Oslo, Norway, 0424